Here's a list of suggestions:
During interactions with NPCs, assign a standing position for your helper so that they don't stand in your line of sight while talking to them, thus blocking the entire screen.
Don't allow the helper to stand in front of you from the direction your camera is facing while interacting with wisps after you kill them. Often times, they will walk in front of you to collect the essence, but they get in the way and you miss out on 1-2 procs for essence extraction.
Don't allow helpers to stand directly in the center of where your camera is facing unless you are in combat. My house's inventory room is very compact and the helper will often stand in the way of an inventory chest, crafting station, or pepys box I don't like having to walk outside so my helper will stand in place out of the way.